Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Basu, S.
Right arrow Articles by Srivastava, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Basu, S.
Right arrow Articles by Srivastava, P. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 15, No. 9, pp. 1053-1061, September 2003
© 2003 Japanese Society for Immunology

Fever-like temperature induces maturation of dendritic cells through induction of hsp90

Sreyashi Basu1 and Pramod K. Srivastava1

1 Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, MC1601, Farmington, CT 06030-1601, USA

Correspondence to: P. Srivastava; E-mail: srivastava{at}nso2.uchc.edu
Transmitting editor: P. S. Ohashi

Fever is a phylogenetically conserved biological phenomenon and a common consequence of infection. Here, we examine in vitro and in vivo the effect of febrile temperature on dendritic cells (DC), a key antigen-presenting cell in the immune system. Elevated temperatures are observed to cause immature DC to mature, specifically through elevation of intracellular levels of hsp90. Surprisingly, even brief exposure to elevated temperatures has a powerful effect on the immunostimulatory capacity of DC. These results bear on the mechanisms of the salutary effects of fever as well as of behavioral elevations of temperature such as saunas and warm blankets.

Keywords: dendritic cell, fever, hsp90


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
P. Murapa, S. Gandhapudi, H. S. Skaggs, K. D. Sarge, and J. G. Woodward
Physiological Fever Temperature Induces a Protective Stress Response in T Lymphocytes Mediated by Heat Shock Factor-1 (HSF1)
J. Immunol., December 15, 2007; 179(12): 8305 - 8312.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. S. Hatzfeld-Charbonnier, A. Lasek, L. Castera, P. Gosset, T. Velu, P. Formstecher, L. Mortier, and P. Marchetti
Influence of heat stress on human monocyte-derived dendritic cell functions with immunotherapeutic potential for antitumor vaccines
J. Leukoc. Biol., May 1, 2007; 81(5): 1179 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Bachleitner-Hofmann, M. Strohschneider, P. Krieger, M. Sachet, P. Dubsky, H. Hayden, S. F. Schoppmann, R. Pfragner, M. Gnant, J. Friedl, et al.
Heat Shock Treatment of Tumor Lysate-Pulsed Dendritic Cells Enhances Their Capacity to Elicit Antitumor T Cell Responses against Medullary Thyroid Carcinoma
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4571 - 4577.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Basu and P. Srivastava
Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells
PNAS, April 5, 2005; 102(14): 5120 - 5125.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
V. Milani, B. Frankenberger, O. Heinz, A. Brandl, S. Ruhland, R. D. Issels, and E. Noessner
Melanoma-associated antigen tyrosinase but not Melan-A/MART-1 expression and presentation dissociate during the heat shock response
Int. Immunol., March 1, 2005; 17(3): 257 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Cippitelli, C. Fionda, D. Di Bona, M. Piccoli, L. Frati, and A. Santoni
Hyperthermia Enhances CD95-Ligand Gene Expression in T Lymphocytes
J. Immunol., January 1, 2005; 174(1): 223 - 232.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.