International Immunology, Vol. 15, No. 6, pp. 773-779,
June 2003
© 2003 Japanese Society for Immunology
FEATURED ARTICLE OF THE MONTH |
Distinct antigen trafficking from skin in the steady and active states
1 Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, and 2 Division of Oral and Maxillofacial Biopathological Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan 3 Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan 4 Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu 500-8705, Japan
Correspondence to: M. Yoshino, Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. E-mail: myoshi{at}grape.med.tottori-u.ac.jp
Transmitting editor: T. Hamaoka
In antigen trafficking from the skin, it has been postulated that Langerhans cells/dendritic cells are activated after capturing exogenous antigens, up-regulate the expression of the chemokine receptor, CCR7, and migrate into lymphoid organs in response to the signaling of a chemokine, CCL21, which is expressed in lymphatic vessels and T cell zone stromal cells. Here we demonstrate that there is a distinct pathway of antigen trafficking from skin in the steady state that is independent of CCL21–CCR7 signaling. Employing melanin granules as an endogenous traceable antigen, we developed a system for visualizing antigen trafficking using mice with melanocytosis in the skin. We found the abrogation of antigen trafficking into regional lymph nodes (LN) in CCL21-Ser-deficient paucity of lymph node T cells (plt) mice in the active state induced by lipopolysaccharide injection, corresponding with previous reports, but normal accumulation of antigen in regional LN under steady-state conditions. These findings suggest that self-antigen is trafficking constitutively using pathway(s) other than that of the active state and the constitutive trafficking might regulate self-reactivity of the immune system.
Keywords: dendritic cell, Langerhans cell, lymph node, paucity of lymph node T cell (plt), skin
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