International Immunology, Vol. 15, No. 5, pp. 549-556,
May 2003
© 2003 Japanese Society for Immunology
Regulation of human Fc
RI ß chain gene expression by Oct-1
1 Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan 2 Pharmacobioregulation Research Laboratory, Hanno Research Center, Taiho Pharmaceutical Co. Ltd, 1-27, Misugidai, Hanno-shi, Saitama 357-8527, Japan 3 Department of Pediatrics, Faculty of Medicine, Kyoto University, 54 Shogoin Sakyo, Kyoto 606-8507, Japan 4 Present address: Advanced Medical Research Center, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan
Corresponding to: C. Nishiyama; E-mail:chinishi{at}med.juntendo.ac.jp
Transmitting editor: S. Koyasu
The ß chain, a component of the high-affinity receptor for IgE (Fc
RI), plays an important role in IgE-mediated allergic reaction. The ß chain accelerates the function of FcRI by amplification of its surface expression and of signal transduction in effector cells such as mast cells and basophils. Two regulatory regions, +60/+66 and +70/+76, for the human ß chain gene that are required for the cell-type-specific transcriptional activation were identified by transient reporter assay. Electrophoretic mobility shift assay demonstrated that Oct-1 binds both the regions, among which the +70/+76 Oct-1 motif was critical for the transactivation of the ß promoter responsive to Oct-1 overexpression. Regulation of ß chain gene expression is discussed.
Keywords: allergy, IgE receptor, transcription factors
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