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International Immunology, Vol. 15, No. 3, pp. 373-382, March 2003
© 2003 Japanese Society for Immunology

Expansion of human {gamma}{delta} T cells after in vitro stimulation with Campylobacter jejuni

Ildiko Van Rhijn1, Leonard H. Van den Berg1, C. Wim Ang3, Joke Admiraal4 and T. Logtenberg2

Departments of 1 Neurology and 2 Immunology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands 3 Departments of Neurology and Immunology, Erasmus University Rotterdam, 3000 VB, Rotterdam, The Netherlands 4 Rijksinstituut voor Volksgezondheid en Milieu, 3720 BA, Bilthoven, The Netherlands

Correspondence to: L. H. Van den Berg; E-mail: l.h.vandenberg{at}neuro.azu.nl
Transmitting editor: K. Sugamura

Campylobacter jejuni is currently the prime cause of food-borne bacterial gastro-enteritis. An important complication of C. jejuni enteritis is Guillain–Barré syndrome (GBS), an immune-mediated disorder of peripheral nerve tissue. Because little is known about T cell reactivity to C. jejuni, we have analyzed the in vitro immune response of normal individuals against five isolates of C. jejuni representing five different serotypes. We found a preferential expansion of peripheral blood {gamma}{delta} T cells after exposure to crude sonicates of all five C. jejuni serotypes. Expansion of {gamma}{delta} T cells was dependent on the presence of CD4+/{alpha}ß+ T cells in the cultures or addition of exogenous IL-2 or IL-15. C. jejuni stimulation was mediated via the TCR and appeared to be induced by a non-proteinaceous bacterial antigen, most likely of phosphoantigenic origin.

Keywords: bacterial serotype, CD4+ {alpha}ß T cells, Guillain–Barré syndrome, IL-2, IL-15


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