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International Immunology, Vol. 15, No. 3, pp. 301-312, March 2003
© 2003 Japanese Society for Immunology

Asynchronous differentiation models explain bone marrow labeling kinetics and predict reflux between the pre- and immature B cell pools

Ramit Mehr1, Gitit Shahaf1, Alex Sah2 and Michael Cancro2

1 Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel 2 Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA

Correspondence to: R. Mehr; E-mail: mehrra{at}mail.biu.ac.il
Transmitting editor: I. Pecht

B lymphopoiesis has historically been depicted as a unidirectional process, in which cohorts of developing cells transit through successive differentiative stages in an irreversible, synchronous manner. Here, we examine this view by combining kinetic analysis of developing B cell subsets in the bone marrow with mathematical modeling. Our bromo-deoxyuridine (BrdU) labeling data are incompatible with B cell development being a synchronous process, because labeling curves are non-linear. Moreover, we show that B cell development may not be completely unidirectional, because our results support the possibility of a phenotypic ‘reflux’ among the immature to thepre-B cell subsets.

Keywords: B lymphocyte subsets, bromo-deoxyuridine, mathematical model


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