International Immunology, Vol. 15, No. 12, pp. 1485-1494,
December 2003
© 2003 Japanese Society for Immunology
ß-Catenin expression enhances generation of mature thymocytes
1 Dana Farber Cancer Institute and 2 Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Correspondence to: J. M. Sen; E-mail: jyoti_sen{at}dfci.harvard.edu
Transmitting editor: A. Singer
T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that ß-catenin, a central effector in the Wnt–TCF-1 signaling pathway, regulates late stages of T cell development. Specifically, transgenic expression of ß-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt–ß-catenin–TCF-1 signaling pathway plays a role during late stages of T cell development.
Keywords: positive selection, signal transduction, thymocyte maturation, thymus, Wnt signaling
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