International Immunology, Vol. 15, No. 1, pp. 49-58,
January 2003
© 2003 Japanese Society for Immunology
IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
Departments of 1 Microbiology and Immunology, and 2 Medicine, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA
Correspondence to: P. D. Katsikis; E-mail: katsikis{at}drexel.edu
Transmitting editor: K. Okumura
Although the effect of IL-15 has been described on murine cells in vitro and in vivo, its effect on human memory CD8+ T cells is not well characterized. We show here that IL-15 preferentially enhances the activation and effector function of human effector-memory CD45RA–CD62L– and CD45RA+CD62L– CD4+ and CD8+ T cells in both healthy and HIV-infected individuals. We find that IL-15 increases 2- to 5-fold both the activation and secretion of the effector cytokines IFN-
and tumor necrosis factor (TNF)-
by anti-CD3-stimulated purified CD4+ and CD8+ T cells and peripheral blood mononuclear cells from healthy and HIV-infected individuals. Furthermore, IL-15 potently inhibits CD95/Fas-induced apoptosis of the effector-memory CD4+ and CD8+ T cells from HIV-infected individuals. These findings suggest that in addition to being a growth and survival factor for memory CD8+ T cells, IL-15 is also a potent activator of human effector-memory CD8+ T cells both in healthy and in HIV-infected individuals.
Keywords: apoptosis, CD69, HIV, IFN-, lymphocyte activation
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