International Immunology, Vol. 15, No. 1, pp. 119-125,
January 2003
© 2003 Japanese Society for Immunology
Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis
1 Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA 2 Present address: Department of Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands 3 Present address: Department of Immunology, University of Washington, Seattle, WA 98195, USA
Correspondence to: R. G. van der Most; E-mail: r.g.vandermost{at}vet.uu.nl
Transmitting editor: T. Hünig
Dengue virus infection in the central nervous system (CNS) of immunized mice results in a strong influx of CD8 T cells into the brain. Whereas the kinetics of the splenic antiviral response are conventional, i.e. expansion followed by a rapid drop in the frequency of specific CD8 T cells, dengue virus-specific CD8 T cells are retained in the CNS at a high frequency. These CD8 T cells display a partially activated phenotype (CD69high, Ly-6A/Ehigh, CD62Llow), characteristic for effector-memory T cells. CD43 expression, visualized by staining with the 1B11 mAb, decreased in time, suggesting that these persisting CD8 T cells differentiated into memory cells. These data add to the growing evidence implicating the CNS as a non-lymphoid tissue capable of supporting prolonged T cell survival/maintenance.
Keywords: effector-memory CD8 T cell, lymphocyte retention, viral infection
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