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International Immunology, Vol. 14, No. 9, pp. 1075-1083, September 2002
© 2002 Japanese Society for Immunology

Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells

Randall S. Davis1,3, Haitao Li2, Ching-Cheng Chen2, Yui-Hsi Wang2, Max D. Cooper2,7 and Peter D. Burrows2,6

Divisions of 1 Hematology/Oncology, and 2 Developmental and Clinical Immunology; Departments of 3 Medicine, 4 Pediatrics, 5 Pathology and 6 Microbiology; and 7 Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300, USA

Correspondence to: P. D. Burrows, WTI 378, 1530 3rd Avenue South, Birmingham, AL 35294-3300, UDA. E-mail: peterb{at}uab.edu
Transmitting editor: T. Watanabe

The recent identification of five human Fc receptor (FcR) homologs, hFcRH1–5, has extended the known FcR family and identified an unanticipated richness of the chromosome 1q region in genes encoding potential Ig-binding proteins. In a database search for additional relatives of this family we identified expressed sequence tag representatives of a new FcR-related molecule (hFcRX) and its mouse ortholog (mFcRX). The FcRX cDNAs were cloned from human lymph node and mouse spleen cDNA libraries. hFcRX is located centromeric of Fc{gamma}RII and Fc{gamma}RIII at 1q23, and its mouse ortholog resides in a syntenic region of chromosome 1. The genes encode proteins with 67% interspecies identity that lack both N-linked glycosylation sites and transmembrane regions. Two of the four FcRX domains are Ig-like, and share characteristics similar to Fc{gamma}RI domains 2 and 3, having 28% overall extracellular identity with hFc{gamma}RI and 27% identity with mFc{gamma}RI respectively. FcRX transcripts are found primarily in secondary lymphoid tissues, where they are expressed by B lineage cells. FcRX thus may function as a secreted or intracellular protein in normal and neoplastic B cells.

Keywords: B cell-specific gene, chromosome 1, Fc receptor


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