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International Immunology, Vol. 14, No. 7, pp. 823-830, July 2002
© 2002 Japanese Society for Immunology

Anti-ß2-glycoprotein I antibodies in children with atopic dermatitis

Ales Ambrozic1, Tadej Avicin2, Kenji Ichikawa3, Tanja Kveder1, Eiji Matsuura4, Maja Hojnik1, Tatsuya Atsumi3, Blaz Rozman1 and Takao Koike3

Departments of 1 Rheumatology and 2 Pediatrics, University Medical Centre, Vodnikova 62, 1000 Ljubljana, Slovenia 3 Department of Medicine II, Hokkaido University School of Medicine, Sapporo 060-8638, Japan 4 Department of Cell Chemistry, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700-8558, Japan

Correspondence to: A. Ambrozic; E-mail: ales.ambrozic{at}mf.uni-lj.si
Transmitting editor: T. Saito

ß2-Glycoprotein I (ß2GPI) appears to be the major antigen for antiphospholipid antibodies (aPL) in patients with antiphospholipid syndrome (APS). In early infancy, virtually all children initiate transient immune response to non-pathogenic nutritional antigens, which fails to terminate in children with atopic diseases. To examine the possibility that a prolonged immune response to ß2GPI could also spread to the human protein, antibodies against human ß2GPI (anti-ß2GPI) were determined in 93 randomly selected children with different allergic diseases. A high frequency (42%) of IgG anti-ß2GPI was found in children with atopic dermatitis (AD), but not in those with other allergic diseases. Anti-ß2GPI in children with AD were exclusively of the IgG1 subclass and bound to bovine ß2GPI as well, but not to either ß2GPI combined with the phospholipid cardiolipin. The epitopes were identified in domain V of ß2GPI and the antibody binding was abolished upon the specific proteolytic cleavage of the phospholipid-binding C-terminal loop in domain V of ß2GPI. These results indicated that the epitopes for anti-ß2GPI in children with AD most likely resided in close vicinity of the phospholipid-binding site of ß2GPI. The epitopic difference from anti-ß2GPI in APS may explain presumed non-thrombogenicity of anti-ß2GPI in children with AD.

Keywords: allergy, antigen, antiphospholipid antibody, autoantibody, autoimmunity, epitope


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