Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wang, Y.-D.
Right arrow Articles by Zhang, X.-G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, Y.-D.
Right arrow Articles by Zhang, X.-G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 14, No. 6, pp. 599-603, June 2002
© 2002 Japanese Society for Immunology

gp130-linked signal transduction promotes the differentiation and maturation of dendritic cells

Yue-Dan Wang1, Zong-Jiang Gu1, Jian-An Huang1,1, Yi-Bei Zhu1, Zhao-Hua Zhou1, Wei Xie1, Ying Xu1, Yu-Hua Qiu1 and Xue-Guang Zhang1

1 Department of Immunology, Soochow (Suzhou) University, 48 Renmin Road, Suzhou, China 215007 2 Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, 96 St. Shizi, Suzhou, China 215006

The first two authors contributed equally to this work
Correspondence to: X. G. Zhang; E-mail: smbxuegz{at}public1.sz.js.cn
Transmitting editor: M. Nussenzweig

In order to explore the role of gp130-linked signal transduction in the differentiation and maturation of dendritic cells (DC), the mAb, B-S12, an agonist of gp130, was used for the activation of gp130 on DC. The effects of cytokines and of anti-gp130 mAb on the proliferation of DC, and their expression of IL-12 and CD80 (B7-1) by DC were evaluated. DC differentiating from peripheral blood mononuclear cells did not express the IL-6 receptor {alpha} chain, but expressed gp130. Anti-gp130 mAb promoted the proliferation of DC, induced by IL-4 and granulocyte macrophage colony stimulating factor (GM-CSF), by up-regulating the GM-CSF receptor on DC. DC induced by gp130 mAb and cytokines expressed DC-derived CC chemokine, as measured by RT-PCR. Induced DC also stimulated strong proliferation of autologous T cells in mixed lymphocyte reaction since an up-regulated expression of IL-12 and CD80 (B7-1) was observed in DC activated by anti-gp130 mAb. Thus, gp130 signal transduction is important for the differentiation and maturation of DC.

Keywords: cytokines, dendritic cells, gp130 molecule, mAb


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int ImmunolHome page
L. Wenxin, F. Jinxiang, W. Yong, L. Wenxiang, S. Wenbiao, and Z. Xueguang
Expression of membrane-bound IL-15 by bone marrow fibroblast-like stromal cells in aplastic anemia
Int. Immunol., April 1, 2005; 17(4): 429 - 437.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.