International Immunology, Vol. 14, No. 4, pp. 339-345,
April 2002
© 2002 Japanese Society for Immunology
Localization of intestinal intraepithelial T lymphocytes involves regulation of 
Eß7 expression by transforming growth factor-ß
1 Atopy (Allergy) Research Center, 2 Department of Pediatrics and 3 Department of Nephrology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
Correspondence to: A. Nakao; Email: anakao{at}med.juntendo.ac.jp
Transmitting editor: M. Miyasaka
Induction of 
Eß7 expression on T cells by transforming growth factor (TGF)-ß is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of Eß7 expression on T cells by TGF-ß is critical for the selective localization of intestinal IEL in the epithelial area. We have recently established transgenic mice expressing Smad7 under the control of a distal lck promoter where TGF-ß/Smad signaling is specifically blocked in mature T cells. Here we showed that TGF-ß-mediated up-regulation of Eß7 was impaired on T cells isolated from the Smad7 transgenic mice associated with reduced numbers of intestinal IEL when compared with that in wild-type littermates. These results indicated that failure to induce Eß7 on T cells by TGF-ß resulted in reduced numbers of intestinal IEL, suggesting the importance of Eß7 expression by TGF-ß in selective localization of intestinal IEL.
Keywords: mucosal immunity, transgenic mice, Smad7
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