International Immunology, Vol. 14, No. 2, 233-239,
February 2002
© 2002 Japanese Society for Immunology
Natural CD4 CD25+ regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10
INSERM U345, Institut Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
Correspondence to: M. Papiernik; E-mail: papiernik{at}necker.fr
In normal mice a subpopulation of CD4 T cells constitutively expresses the IL-2 receptor 
chain (CD25). This natural CD4 CD25+ subset is thymus-born, constitutively expresses IL-10 mRNA,does not produce IL-2 and is resistant to apoptosis. These cells behave as regulatory T cells inthe control of self-tolerance, inflammatory reactions and T cell homeostasis. The mechanisms by which natural CD4 CD25+ cells control the immune response is unclear. We examinedCD25-deficient mice, which over-express various cytokines, including proinflammatory molecules, after bacterial superantigen stimulation in vivo. We observed that this abnormal cytokine production could be controlled by the injection of natural CD4 CD25+ T cells and that IL-10 production is needed, as CD4 CD25+ T cells from IL-10 knockout mice do not correct cytokine over-production in vivo. As the circulating IL-10 produced by CD25-deficient mice was ineffective, we deduced that the key source of IL-10 was the regulatory T cell population. IL-10 is also involved in the control of cytokine production by normal T cells. However, the target of IL-10 in this control is undefined. Whether it acts directly on the effector T cells or on the regulatory CD4 CD25+ T cells themselves to induce their functional maturation has to be clarified.
Keywords: CD4 CD25+, cytokines, IL-10, regulatory CD4 T cells, superantigen
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