International Immunology, Vol. 14, No. 2, 167-175,
February 2002
© 2002 Japanese Society for Immunology
Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or 
4ß7-integrin at the lesions of autoimmune gastritis
Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan
1 Department of Biology, Faculty of Science, Niigata University, Niigata 950-2181, Japan
2 The Health Examination Center, UNITIKA Central Hospital, Uji 611-0021, Japan
Correspondence to: A. Shimizu; E-mail: shimizu{at}virus.kyoto-u.ac.jp
Th1 cells but not Th2 cells accumulate at the inflamed gastric mucosa (GM), while both subsets co-exist in the regional lymph node (RLN) in a murine experimental model for autoimmune gastritis (AIG). To understand the relationship between the immuno-microenvironment and effector localization in GM versus RLN of AIG-bearing mice, cells or tissue sections were stained with several mAb against adhesion molecules. The expression of RNA of various cytokines at these contrasting sites was also assessed. IFN-
-producing memory CD4+ (Th1) and CD8+ T cells as well as IL-12-producing mature macrophages which express P-selectin ligand and/or 
4ß7-integrin selectively accumulated in the inflamed GM. Vessel endothelium at the site of infiltration expressed those counter-receptors, P-selectin and mucosal adressin cell adhesion molecule-1. Therefore, the tissue destruction of target tissue in autoimmune diseases might be promoted by a vicious circle between the selective accumulation of type 1 effectors mediated by multiple adhesion molecules and following an unusual type 1-biased microenvironment away from the type 2 response.
Keywords: CD4+ T cell subset, immuno-microenvironment, neonatal thymectomy
Transmitting editor: T. Kurosaki
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