Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Abraham, M.
Right arrow Articles by Miller, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abraham, M.
Right arrow Articles by Miller, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 14, No. 12, pp. 1449-1457, December 2002
© 2002 Japanese Society for Immunology

The role of IL-18 and IL-12 in the modulation of matrix metalloproteinases and their tissue inhibitors in monocytic cells

Michal Abraham1,4, Sarah Shapiro2, Nitza Lahat2,4 and Ariel Miller1,3,4

1 Neuroimmunology and 2 Immunology Research Units, Carmel Medical Center, and 3 Rappaport Institute for Research in the Medical Sciences, and 4 Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, Israel

Correspondence to: A. Miller, Neuroimmunology Unit, Department of Neurology, Carmel Medical Center, 7 Michal Street, Haifa 34362, Israel.E-mail: millera{at}tx.technion.ac.il
Transmitting editor: D. Wallach

The matrix metalloproteinases (MMP) are enzymes crucial for the physiological patrol as well as pathological chemotaxis of immune cells to target tissues. The present study examined differential effects of pro-inflammatory [IL-18, IL-12 and tumor necrosis factor (TNF)-{alpha}] versus anti-inflammatory (IL-4) cytokines on the modulation of MMP and their endogenous tissue inhibitors (TIMP) expression in the U937 cell line. IL-18 and IL-12 separately and synergistically enhanced MMP-2, while TNF-{alpha} led to the elevation of MMP-9. All pro-inflammatory cytokines enhanced MT1-MMP expression and IL-4 suppressed TNF-{alpha}-induced MMP-9 expression. This study demonstrated that elevated IL-18 and IL-12, and related pro-inflammatory activity, may be associated with aberrant MMP activity, suggesting modulation of MMP expression using IL-12 and IL-18 antagonists as future therapeutic strategies to attenuate inflammatory and autoimmune disorders.

Keywords: autoimmunity, cytokines, gelatinases, IL-4, immunomodulation, tumor necrosis factor-{alpha}


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Zirlik, S. M. Abdullah, N. Gerdes, L. MacFarlane, U. Schonbeck, A. Khera, D. K. McGuire, G. L. Vega, S. Grundy, P. Libby, et al.
Interleukin-18, the Metabolic Syndrome, and Subclinical Atherosclerosis: Results From the Dallas Heart Study
Arterioscler Thromb Vasc Biol, September 1, 2007; 27(9): 2043 - 2049.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. Melamed, O. Messika, L. Glass-Marmor, and A. Miller
Modulation of matrix metalloproteinase-9 (MMP-9) secretion in B lymphopoiesis
Int. Immunol., September 1, 2006; 18(9): 1355 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhou, F. Li, L. Kong, H. Tomita, C. Li, and W. Cao
Involvement of Inflammation, Degradation, and Apoptosis in a Mouse Model of Glaucoma
J. Biol. Chem., September 2, 2005; 280(35): 31240 - 31248.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A.D. Hauer, C. Uyttenhove, P. de Vos, V. Stroobant, J.C. Renauld, T.J.C. van Berkel, J. van Snick, and J. Kuiper
Blockade of Interleukin-12 Function by Protein Vaccination Attenuates Atherosclerosis
Circulation, August 16, 2005; 112(7): 1054 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Karmakar, R. Dhar, and C. Das
Inhibition of Cytotrophoblastic (JEG-3) Cell Invasion by Interleukin 12 Involves an Interferon {gamma}-mediated Pathway
J. Biol. Chem., December 31, 2004; 279(53): 55297 - 55307.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
N. Ledee-Bataille, F. Olivennes, J. Kadoch, S. Dubanchet, N. Frydman, G. Chaouat, and R. Frydman
Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer
Hum. Reprod., September 1, 2004; 19(9): 1968 - 1973.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.