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International Immunology, Vol. 14, No. 11, pp. 1357-1367, November 2002
© 2002 Japanese Society for Immunology

Contribution of CD3{gamma} to TCR regulation and signaling in human mature T lymphocytes

Pilar S. Torres1, David A. Zapata1, Alberto Pacheco-Castro1, José L. Rodríguez-Fernández2, Carlos Cabañas2 and José R. Regueiro1

1 Inmunología and 2 Bioquímica y Biología Celular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain

Correspondence to: J. R. Regueiro; E-mail: regueiro{at}med.ucm.es
Transmitting editor: F. Rosen

CD3 proteins may have redundant as well as specific contributions to the intracellular propagation and final effector responses of TCR-mediated signals at different checkpoints during T cell differentiation. We report here on the participation of CD3{gamma} in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint. Following TCR–CD3 engagement of human CD3{gamma}-deficient T cell lines, and despite their lower TCR–CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, including the TCR–CD3 itself, were either normal or only slightly affected. In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased. Our data indicate that CD3{gamma} contributes essential specialized signaling functions to certain mature T cell responses. Failure to generate appropriate interactions may abort cytoskeleton reorganization and initiate an apoptotic response.

Keywords: cell death, immunodeficiency disease, polarization, signal transduction, surface molecule


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