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International Immunology, Vol. 14, No. 11, pp. 1239-1245, November 2002
© 2002 Japanese Society for Immunology

Restoration of ethanol-compromised Th1 responses by sodium orthovanadate

Serge Ostrovidov1, Laurence M. Howard1, Masato Ikeda1, Akiko Ikeda1 and Carl Waltenbaugh1

1 Department of Microbiology–Immunology, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA

Correspondence to: C. Waltenbaugh; E-mail: waltenbaugh{at}northwestern.edu
Transmitting editor: D. R. Green

Alcohol consumption often diminishes antigen-specific cell-mediated immunity. In alcohol-consuming mice IFN-{gamma} and delayed-type hypersensitivity (DTH) responses are blunted, although antigen-specific T cell proliferation and IL-2 responses are largely unaffected, suggesting that alcohol differentially affects signal transduction pathways. In the present report we explore the use of the phosphatase inhibitor, Na3VO4 to restore IFN-{gamma} secretion in the presence of ethanol both in vivo and in vitro. We show that Na3VO4 restores IFN-{gamma} in vitro and antigen-specific DTH in vivo to the levels seen in alcohol non-consuming mice. Our data support the contention that ethanol, by up-regulating phosphotyrosine phosphatase, diminishes the IFN-{gamma} signal transduction pathway.

Keywords: alcohol, IFN-{gamma}, mouse, Na3VO4, protein tyrosine phosphatase


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