International Immunology, Vol. 14, No. 10, pp. 1099-1104,
October 2002
© 2002 Japanese Society for Immunology
Differential regulation of CD36 expression in antigen-presenting cells: Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages
1 The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia 2 Department of Medicine, Division of Hematology and Medical Oncology, Cornell University, New York, NY 10021, USA
Correspondence to: L. Corcoran; E-mail: corcoran{at}wehi.edu.au.
Transmitting editor: A. Kelso
In mice, three antigen-presenting cell types [B lymphocytes, macrophages and dendritic cells (DC)] express the scavenger receptor CD36. This molecule has been implicated in many important functions, including DC maturation and antigen presentation. In murine B cells, the CD36 gene requires the Oct-2 transcription factor for its expression. We previously found that B cells from Oct-2-null mice display defects in maturation, survival and proliferation. Here we have looked for a possible role for CD36 in B cells, but found that CD36 is dispensable for all responses tested. Although loss of CD36 did not directly affect B cell function, it did modulate slightly the isotype and level of IgG produced in vivo in naive mice, and IgM in Leishmania-infected mice. We also show that in DC and macrophages, CD36 expression is independent of Oct-2. We conclude that CD36 does not play a major role in B cell function, but that CD36 may contribute indirectly to humoral immunity through cells of the innate immune system.
Keywords: B lymphocyte, dendritic cell, Leishmania major, monocyte/macrophage, transgenic/knockout
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