International Immunology, Vol. 13, No. 9, 1185-1192,
September 2001
© 2001 Japanese Society for Immunology
Distinct requirements for IL-6 in polyclonal and specific Ig production induced by microorganisms
Unit of Experimental Medicine,
1 Ludwig Institute for Cancer Research, Christian de Duve Institute of Cellular Pathology and
2 Microbiology Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 74, 1200 Bruxelles, Belgium
Correspondence to: D. Markine-Goriaynoff
The role of IL-6 in Ig production induced in the mouse by lactate dehydrogenase-elevating virus (LDV), Toxoplasma gondii or lipopolysaccharide (LPS) was assessed. Following infection with LDV, a strong activator of B cells, an early and transient IL-6 production was observed, that originated predominantly from macrophages. Whereas LDV-induced B lymphocyte proliferation appeared independent of IL-6, mice deficient for this cytokine showed a marked reduction in their total T-dependent IgG2a production when compared to their normal counterparts. By contrast, specific responses directed against either LDV or non-viral antigens administered at the time of infection were not decreased in the absence of IL-6. Similarly, polyclonal, but not anti-parasite IgG2a production triggered by T. gondii infection was strongly dependent on the presence of IL-6. Finally, T-independent total IgG3 secretion triggered by LPS was also markedly reduced in IL-6-deficient mice. These results suggest that IL-6 plays a major role in T-dependent and T-independent polyclonal Ig production following B lymphocyte activation by viruses, and parasites, but not in specific antibody responses induced by the same microorganisms.
Keywords: cytokine, IL-6, antibody isotype, lactate dehydrogenase-elevating virus, lipopolysaccharide, Toxoplasma gondii
Transmitting editor: A. Radbruch
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