International Immunology, Vol. 13, No. 6, 763-768,
June 2001
© 2001 Japanese Society for Immunology
T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo
Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS/INSERM/ULP), 1 rue Laurent Fries, 67404 Illkirch, C. U. de Strasbourg, France
Correspondence to: C. Benoist and D. Mathis, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
The role of IL-4, -6 and -7 in the survival of T lymphocytes was studied in vivo. The decay of polyclonal populations of CD4+ and CD8+ T cells was monitored in thymectomized anti-cytokine receptor mAb-treated and/or cytokine-deficient mice. The lack of IL-4 or -6 did not have any detectable effect on T cell survival, but IL-7 played an important role in the survival of the naive T cell compartment, especially of naive CD4+ T cells.
Keywords: cytokine, homeostasis, IL, signaling, survival, T cell
1 Present address: Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
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