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International Immunology, Vol. 13, No. 4, 593-600, April 2001
© 2001 Japanese Society for Immunology

CD11b expression as a marker to distinguish between recently activated effector CD8+ T cells and memory cells

J. Erbo Christensen, S. Ørding Andreasen, J. Pravsgaard Christensen and A. Randrup Thomsen

Institute of Medical Microbiology and Immunology, University of Copenhagen, Panum Institute, 3C Blegdamsvej, 2200 Copenhagen N, Denmark

Correspondence to: A. Randrup Thomsen

CD8+ T cells in different activation states have been difficult to identify phenotypically. In this study we have investigated whether Mac-1 (CD11b) expression can be used as a criterion to distinguish between recently activated effector cells and memory cells belonging to the CD8+ T cell subset. Polyclonal virus-specific effector and memory CD8+ T cells from lymphocytic choriomeningitis- and vesicular stomatitis virus-infected mice were visualized through staining for intracellular IFN-{gamma} or binding of MHC–peptide tetramers, and Mac-1 expression was evaluated. Naive T cells and most virus-specific memory CD8+ T cells express little or no Mac-1 independent of the virus model employed. In contrast, the majority of CD8+ T cells present during acute infection express a significant level of Mac-1 and, similarly, Mac-1 expression is found on secondary effectors generated in response to viral re-exposure. We therefore suggest that high Mac-1 expression defines a subset of circulating effector cells and that the presence of this marker on antigen-specific CD8+ T cells signifies recent activation.

Keywords: T cell memory, T cell phenotype, viral infection

Transmitting editor: A. McMichael


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