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Correction for Tian et al., Int. Immunol. 0 (2005) dxh306v1.
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International Immunology, Vol. 13, No. 3, 313-320, March 2001
© 2001 Japanese Society for Immunology

Heterogeneity within medullary-type TCR{alpha}ß+CD3+CD4–CD8+ thymocytes in normal mouse thymus

Tain Tian, Jun Zhang, Lin Gao, Xiao Ping Qian and Wei-Feng Chen

Department of Immunology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China

Correspondence to: W.-F. Chen.

The functional maturation process of medullary-type CD4–CD8+ [CD8 single-positive (SP)] thymocytes remains largely uncharacterized. We describe a phenotypic analysis of CD8 SP medullary-type thymocytes and find a remarkable heterogeneity within this thymic cell population. While mature CD8+ T cells in the periphery are relatively homogenous (TCR{alpha}ß+CD3+Qa-2+ HSA–3G11–6C10–CD69–), CD8 SP medullary-type thymocytes contain discrete subpopulations that can be identified by differential expression of several cell-surface markers. We have identified at least six discrete subpopulations in the subset of TCR{alpha}ß+CD3+ CD8 SP cells in the thymus. According to the expressed phenotypes, a linear developmental pathway is predicted among these CD8 SP subpopulations as follows: 6C10+CD69+HSAhi3G11+Qa-2– -> 6C10–CD69+HSAhi/int3G11+Qa-2– -> 6C10–CD69–HSAint3G11+Qa-2– -> 6C10–CD69–HSAlo3G11+Qa-2– -> 6C10–CD69–HSA–/lo3G11–Qa-2– -> 6C10–CD69–HSA–/lo3G11–Qa-2+. This study provides a framework for understanding CD8 SP T cell maturation in the thymic medulla.

Keywords: heterogeneity, medullary-type thymocytes, phenotypes

Transmitting editor: A. Singer


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