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International Immunology, Vol. 13, No. 12, 1453-1459, December 2001
© 2001 Japanese Society for Immunology

A central role for IL-2 in fate determination of mature T cells—I: role in determining the Th1/Th2 profile in primary T cell cultures

Kaliannan Raju, Brian A. Rabinovich, Laszlo G. Radvanyi,1, David Spaner,2 and Richard G. Miller

Departments of Medical Biophysics and Immunology, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto M5G 2M9, Canada

Correspondence to: R. G. Miller

IL-2 signaling appears to play a significant role in enabling the synthesis of Th2 cytokines in an in vitrosystem for studying primary T cell responses. When T cells from C57BL/6J or BALB/c strains of mice were activated in vitroand re-stimulated through their TCR complex 48 h later, CD4+ T cells producing the Th2 cytokines IL-4 and IL-10 were found only when IL-2 was present. IL-2 also enhanced IFN-{gamma} synthesis in C57BL/6J cells but not in BALB/c cells. By up-regulating production of anti-inflammatory Th2 cytokines during a primary response, IL-2 may play a critical role in limiting Th1-mediated responses.

Keywords: autoimmunity, IFN-{gamma}, IL-2, IL-4, IL-5, IL-10, Th1, Th2, tumor necrosis factor-{gamma}

1 Present address: Immunology Department, Aventis Pasteur, Sunnybrook and Women's College Health Science Centre, Toronto M4N 3N5, Canada

2 Present address: Division of Cancer Biology Research, Sunnybrook and Women's College Health Science Centre, Research Building, Toronto M4N 3N5, Canada

Transmitting editor: J. W. Schrader


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