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International Immunology, Vol. 13, No. 1, 75-83, January 2001
© 2001 Japanese Society for Immunology

CD4+Thy1- thymocytes with a Th-type 2 cytokine response

Douglas M. Cerasoli1, Garnett Kelsoe and Marcella Sarzotti

Department of Immunology, Duke University Medical Center, Box 3010, Durham, NC 27710, USA
1 Present address: Division of Biochemistry and Pharmacology, United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, APG, MD 21010-5425, USA

Correspondence to: M. Sarzotti

We have identified a small subset of CD3+, CD4+, CD8– thymocytes that do not express Thy1 (CD90). This Thy1– subset represents 1–3.7% of the total number of thymocytes in a naive mouse. CD4+Thy1– thymocytes express high levels of CD3, intermediate to high levels of heat-stable antigen (HSA), and low levels of CD25, CD45RB, CD69, CD44 and CD62L. They produce high titers of IL-4 and no IFN-{gamma} upon stimulation in vitro, a response characteristic of Th2 cells. In the thymi of mice infected neonatally with a high dose of the retrovirus Cas-Br-E MuLV, the frequency of CD4+Thy1– cells increased ~10-fold. High-dose virus infection resulted in decreased HSA and increased CD44 expression on CD4+Thy1– cells relative to cells from naive mice. CD4+Thy1– cells from high-dose infected mice also secreted IL-4 and not IFN-{gamma} upon in vitro stimulation. We previously reported that infection of newborn mice with a high dose of murine retrovirus results in the induction of a non-protective anti-viral Th2 T cell response; CD4+Thy1– thymocytes with a Th2-like cytokine profile may play a role in determining the cytokine bias of this anti-viral response.

Keywords: Cas-Br-E MuLV, CD4+ cells, newborn mice, Th2, Thy1– thymocytes, thymic atrophy

Transmitting editor.Z. Ovary


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