Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Iwasaki, M.
Right arrow Articles by Hamaoka, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwasaki, M.
Right arrow Articles by Hamaoka, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 12, No. 5, 701-709, May 2000
© 2000 Japanese Society for Immunology

Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models

Masayuki Iwasaki, Wen-Gong Yu, Yasuhiro Uekusa, Chigusa Nakajima, Yi-Fu Yang, Ping Gao, Rishani Wijesuriya, Hiromi Fujiwara and Toshiyuki Hamaoka

Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan

Correspondence to: H. Fujiwara

While IL-12 administration induces tumor regression through stimulating T cells in tumor-bearing mice, this IL-12 effect is observed in some but not all tumor models. The present study aimed to compare IL-12 responsiveness of T cells from tumor-bearing mice in IL-12-responsive (CSA1M and OV-HM) and -unresponsive (Meth A) tumor models. Tumor regression in IL-12-responsive tumor models required the participation of T cells, but not of NK1.1+ cells. Because a NK1.1+ cell population was the major producer of IFN-{gamma}, comparable levels of IFN-{gamma} production were induced in IL-12-responsive and -unresponsive tumor-bearing mice. This indicates that the amount of IFN-{gamma} produced in tumor-bearing individuals does not correlate with the anti-tumor efficacy of IL-12. In contrast, IL-12 responsiveness of T cells differed between the responsive and unresponsive models: purified T cells from CSA1M/OV-HM-bearing or Meth A-bearing mice exhibited high or low IL-12 responsiveness respectively, when evaluated by the amounts of IFN-{gamma} produced in response to IL-12. T cells from CSA1M- or OV-HM-bearing but not from Meth A-bearing mice exhibited enhanced levels of mRNA for the IL-12 receptor (IL-12R). These results indicate that a fundamental difference exists in IL-12 responsiveness of T cells between IL-12-responsive and -unresponsive tumor models, and that such a difference is associated with the expression of IL-12R on T cells.

Keywords: IL-12, NK cells, tumor models

Transmitting editor: T. Saito


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
Y. Uekusa, P. Gao, N. Yamaguchi, M. Tomura, T. Mukai, C. Nakajima, M. Iwasaki, N. Takeuchi, T. Tsujimura, M. Nakazawa, et al.
A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses
J. Leukoc. Biol., November 1, 2002; 72(5): 864 - 873.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. G. Segal, N. C. Lee, Y. L. Tsung, J. A. Norton, and K. Tsung
The Role of IFN-{gamma} in Rejection of Established Tumors by IL-12 : Source of Production and Target
Cancer Res., August 15, 2002; 62(16): 4696 - 4703.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Uekusa, W.-G. Yu, T. Mukai, P. Gao, N. Yamaguchi, M. Murai, K. Matsushima, S. Obika, T. Imanishi, Y. Higashibata, et al.
A Pivotal Role for CC Chemokine Receptor 5 in T-Cell Migration to Tumor Sites Induced by Interleukin 12 Treatment in Tumor-bearing Mice
Cancer Res., July 1, 2002; 62(13): 3751 - 3758.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. N. Le, N. C. Lee, K. Tsung, and J. A. Norton
Pre-Existing Tumor-Sensitized T Cells Are Essential for Eradication of Established Tumors by IL-12 and Cyclophosphamide Plus IL-12
J. Immunol., December 15, 2001; 167(12): 6765 - 6772.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.