International Immunology, Vol. 12, No. 5, 631-638,
May 2000
© 2000 Japanese Society for Immunology
Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
1 Department of Immunology and
2 Department of Cell Signaling, DNAX Research Institute, Palo Alto, CA 94304, USA
3 Ludwig Institute for Cancer Research and Virology and Cell Biology Section, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2, UK
4 National Institute for Medical Research, Mill Hill, London NW7, UK
5 Department of Cancer Biology and Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
6 Whitehead Institute, MIT, Cambridge, MA 02142, USA
Correspondence to: E. Lees
Progression into G1 in B lymphocytes is regulated by cyclins D2 and D3, components of the cell cycle machinery currently believed to have overlapping and potentially redundant roles in cell cycle control. To study the specific role of cyclin D2 in B lymphocyte proliferation, we examined B cells from cyclin D2–/– mice and demonstrate a specific requirement for cyclin D2 in BCR- but not CD40- or lipopolysaccharide-induced proliferation. Furthermore, conventional B cell development proceeds normally in the mutant mice; however, the CD5 B cell compartment is dramatically reduced, suggesting that cyclin D2 is important in CD5 B cell development as well as antigen-dependent B cell clonal expansion.
Keywords: anti-Ig, B1 B cells, B-CLL, cell cycle, chronic lymphocytic leukemia
7 Present address: Corixa Corp., Redwood City, CA 94063, USA
Transmitting editor: J. Kearney
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