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International Immunology, Vol. 12, No. 5, 597-605, May 2000
© 2000 Japanese Society for Immunology

Regulatory role of mature B cells in a murine model of inflammatory bowel disease

Emiko Mizoguchi, Atsushi Mizoguchi, Frederic I. Preffer and Atul K. Bhan

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street–Cox 5, Boston, MA 02114, USA

Correspondence to: A. K. Bhan

The spontaneous chronic colitis in TCR {alpha} mutant (TCR{alpha}–/–) mice mediated by CD4+ TCR{alpha}–ß+ T cells is more severe in the absence of mature B cells, suggesting a suppressive role of B cells and Ig in the development of chronic colitis. To investigate the direct role of B cells in the suppression of this colitis, cell transfer studies were performed in TCR{alpha}–/– x Igµ–/– ({alpha}µ–/–) double-knockout mice. The chronic colitis was markedly attenuated in {alpha}µ–/– mice after the adoptive transfer of peripheral B cells from TCR{alpha}–/– mice into 3- to 4-week-old {alpha}µ–/– mice prior to the development of colitis. Furthermore, transfer of mature B cells from TCR{alpha}–/– mice markedly decreased the number of pathogenic colonic CD4+ TCR{alpha}–ß+ T cells in {alpha}µ–/– mice with established colitis. This B cell effect required the presence of functional co-stimulatory molecules CD40 and B7-2 (CD86) but not B7-1 (CD80). These results indicate that mature B cells play an important role in the development of chronic colitis in TCR{alpha}–/– mice by directly regulating the pathogenic T cells (CD4+ TCR{alpha}–ß+ T cells).

Keywords: adoptive transfer, B cells, colitis, knockout mice, TCR

Transmitting editor: C. Terhorst


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