Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kato, I.
Right arrow Articles by Kudo, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kato, I.
Right arrow Articles by Kudo, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 12, No. 3, 325-334, March 2000
© 2000 Japanese Society for Immunology

Inducible differentiation and apoptosis of the pre-B cell receptor-positive pre-B cell line

Ibuki Kato, Takahiro Miyazaki, Tetsuya Nakamura1 and Akira Kudo

Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan
1 Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan

Correspondence to: A. Kudo

The function of the pre-B cell receptor (pre-BCR) during B cell differentiation is not precisely defined. To investigate the pre-BCR receptor activity, we have established pre-BCR-positive pre-B cell lines that are able to differentiate into immature B cells in vitro. Antibody cross-linking of the pre-BCR induced apoptosis and differentiation accompanied with tyrosine phosphorylation. A specific tyrosine-phosphorylated 43 kDa protein (p43) was found down-stream of the pre-BCR. The results demonstrated the receptor function of pre-BCR, which indicates that a ligand-like molecule or a cross-linking structure on the cell surface is possibly present.

Keywords: apoptosis, gene rearrangement, pre-B cell receptor, surrogate light chain, tyrosine phosphorylation

Transmitting editor: T. Watanabe


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
K. Maki and K. Ikuta
MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCR{gamma} Locus in Response to IL-7R Signaling
J. Immunol., July 1, 2008; 181(1): 494 - 502.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. A. Martin, L. Lu, M. Cascalho, and G. E. Wu
Maintenance of Surrogate Light Chain Expression Induces Developmental Delay in Early B Cell Compartment
J. Immunol., October 15, 2007; 179(8): 4996 - 5005.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Sato, F. Saito-Ohara, J. Inazawa, and A. Kudo
Pax-5 Is Essential for {kappa} Sterile Transcription during Ig{kappa} Chain Gene Rearrangement
J. Immunol., April 15, 2004; 172(8): 4858 - 4865.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Kato, T. Takai, and A. Kudo
The Pre-B Cell Receptor Signaling for Apoptosis Is Negatively Regulated by Fc{gamma}RIIB
J. Immunol., January 15, 2002; 168(2): 629 - 634.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. P. Stephan, E. Elgavish, H. Karasuyama, H. Kubagawa, and M. D. Cooper
Analysis of VpreB Expression During B Lineage Differentiation in {lambda}5-Deficient Mice
J. Immunol., October 1, 2001; 167(7): 3734 - 3739.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Sato, D. Wang, and A. Kudo
Dissociation of Pax-5 from KI and KII Sites During {{kappa}}-Chain Gene Rearrangement Correlates with Its Association with the Underphosphorylated Form of Retinoblastoma
J. Immunol., June 1, 2001; 166(11): 6704 - 6710.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.