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International Immunology, Vol. 12, No. 3, 271-280, March 2000
© 2000 Japanese Society for Immunology

Vß8+ T cells protect from demyelinating disease in a viral model of multiple sclerosis

Kristen M. Drescher1,2,4, Sean L. Johnston2, William Hogancamp1, Gerald H. Nabozny2, Chella S. David2, Ilonna J. Rimm3, Peter J. Wettstein2 and Moses Rodriguez1,2

1 Departments of Neurology and
2 Immunology, Mayo Clinic/Foundation, Rochester, MN 55905, USA
3 Department of Pediatric Oncology, Dana Farber Cancer Institute/Children's Hospital, Boston,MA 02115, USA

Correspondence to: M. Rodriguez, Department of Immunology, Mayo Clinic/Foundation, Guggenheim 428, 200 First Street SW, Rochester, MN 55905, USA

Previous studies illustrated the influence of T cell subsets on susceptibility or resistance to demyelination in the Theiler's murine encephalomyelitis virus (TMEV) model of multiple sclerosis. Genetic segregation analysis showed a correlation with disease phenotype in this model with particular Vß genes. In this study we investigated the contribution of specific Vß TCR to the pathogenesis of virus-induced demyelinating disease. Spectratype analysis of cells infiltrating the CNS early in infection demonstrated an over-representation of Vß8+ T cells in mice expressing a susceptible H-2 haplotype. We infected transgenic mice expressing the Vß8.2 TCR directed against a non-TMEV antigen and found an increase in demyelinating disease in mice of either susceptible or resistant background compared with littermate controls. In addition, depletion studies with an anti-Vß8-specific antibody in both susceptible (B10.Q) and resistant (C57BL/6) mice resulted in increased demyelination. TCR analysis of VP2-specific cytotoxic T cell clones from mice with a resistant genotype identified only the Vß8.1 TCR, suggesting that limited T cell diversity is critical to TMEV clearance. Together, these results support a protective role for Vß8+ T cells in virus-induced demyelinating disease.

Keywords: demyelination, Theiler's murine encephalomyelitis virus, Theiler's virus

4 Present address: Department of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USA

Transmitting editor: L. Steinman


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