International Immunology, Vol. 12, No. 2, 215-222,
February 2000
© 2000 Japanese Society for Immunology
Ly49A expression on T cells alters T cell selection
Umeå Center for Molecular Pathogenesis and
1 Department of Pathology, Umeå University, 901 87 Umeå, Sweden
2 Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Correspondence to: L. Fahlén
Ly49 receptors are inhibitory receptors expressed on subsets of both NK cells and NK1.1+ T cells. The function of these receptors on NK cells is believed to be important in maintaining self-tolerance, yet their role on T cells is unclear. In this report we investigated how an Ly49A transgene alters T and NK cell development in an in vivo environment, where a ligand for Ly49A is expressed. Ly49A transgenic mice that co-expressed an MHC ligand for Ly49A, H-2Dd, developed a severe inflammatory disorder that resulted in death within the first weeks of age. T cells expressing forbidden TCR Vß chains were found both in the thymus and periphery of transgenic mice, while non-transgenic littermates had successfully deleted these T cell subsets. These data indicate that the expression of Ly49A on T cells could alter T cell selection and allow survival of potentially self-reactive T cells.
Keywords: autoimmunity, NK cells, T lymphocytes, transgenic
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