Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Field, A.-C.
Right arrow Articles by Bellon, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Field, A.-C.
Right arrow Articles by Bellon, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 12, No. 10, 1467-1477, October 2000
© 2000 Japanese Society for Immunology

Neonatal induction of tolerance to Th2-mediated autoimmunity in rats

Anne-Christine Field, Laure Caccavelli, Jacqueline Fillion, Joëlle Kuhn, Chantal Mandet, Philippe Druet1 and Blanche Bellon

INSERM U430 Hôpital Broussais, Pavillon Leriche, 96 rue Didot, 75674 Paris Cedex 14, France
1 INSERM U28 Hôpital Purpan, Pavillon Lefebvre, Place du Dr Baylac, 31059 Toulouse Cedex, France

Correspondence to: B. Bellon

Brown-Norway (BN) rats are highly susceptible to drug-induced immune dysregulations and when injected with mercuric chloride (HgCl2) or sodium aurothiopropanolsulfonate (ATPS), they develop a syndrome characterized by a polyclonal B cell activation depending upon CD4+ Th2 cells that recognize self-MHC class II molecules. Since peripheral tolerance of Th2 cells might be crucial in the prevention of immunological manifestations such as allergy, establishing conditions for inducing tolerance to HgCl2- or ATPS-mediated immune manifestations appeared to be of large interest. We report here that BN rats neonatally injected with HgCl2: (i) do not develop the mercury disease, (ii) remain resistant to HgCl2-induced autoimmunity at 8 weeks of age and later, provided they are regularly exposed to HgCl2, (iii) are still susceptible to ATPS-induced immune manifestations, and (iv) exhibit spleen cells that adoptively transfer tolerance to HgCl2-induced autoimmunity in naive, slightly irradiated, syngeneic recipients. These findings demonstrate that dominant specific tolerance can be neonatally induced using a chemical otherwise responsible for Th2-mediated autoimmunity.

Keywords: heavy metal salts, neonatal tolerance, rodents, Th2 cells

Transmitting editor: H. Bazin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
A.-C. Field, L. Caccavelli, M.-F. Bloch, and B. Bellon
Regulatory CD8+ T Cells Control Neonatal Tolerance to a Th2-Mediated Autoimmunity
J. Immunol., March 1, 2003; 170(5): 2508 - 2515.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.