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International Immunology, Vol. 11, No. 9, 1581-1590, September 1999
© 1999 Japanese Society for Immunology

Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process

Robert J. Hayashi2 and Osami Kanagawa1,3

1 Center for Immunology, and
2 Departments of Pediatrics and
3 Pathology, Washington University School of Medicine, St Louis, MO 63110, USA

Correspondence to: O. Kanagawa, Department of Pathology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA

Mice carrying a transgenic TCR with targeted disruption of the TCR {alpha} chain (H-Y {alpha}–/–) possess CD4+ T cells which express the transgenic TCR ß without the {alpha} chain. These mice developed the murine acquired immunodeficiency syndrome (MAIDS) after infection with LP-BM5 retroviruses, a process which requires CD4+ T cells. These cells are negative for TCR {delta} chain and pre-TCR {alpha} chain expression, and thus express a unique surface receptor with the TCR ß chain as a component. The cells respond to MAIDS virus-associated superantigen and concanavalin A, but not to protein antigens such as ovalbumin. Thus, this novel surface receptor appears to play an important role in the pathogenesis of MAIDS.

Keywords: {alpha} chain deficient, murine acquired immunodeficiency syndrome, receptor, T cell

Transmitting editor: T. Saito


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