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International Immunology, Vol. 11, No. 9, 1509-1518, September 1999
© 1999 Japanese Society for Immunology

Impaired thymopoietic potential of immature CD3–CD4+CD8– T cell precursors from SIV-infected rhesus monkeys

Kai Neben, Marc Heidbreder, Justus Müller1, Anke Marxer, Harald Petry2, Andrea Didier2, Anneliese Schimpl, Thomas Hünig and Thomas Kerkau

Institute of Virology and Immunobiology, University of Würzburg, Versbacher Strasse 7, 97078 Würzburg and
1 Institute of Pathology, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany
2 German Primate Center, Kellnerweg 4, 37077 Göttingen, Germany

Correspondence to: T. Kerkau

Immature thymocyte subpopulations were examined for their capacity to differentiate in a newly developed xenogeneic monkey–mouse fetal thymus organ culture (FTOC) system. We provide evidence for impaired precursor function of CD3–CD4+CD8– thymocytes after in vivo infection with SIVmac251 as indicated by a reduced cell number per FTOC and a lower percentage of thymocytes with more mature phenotypes. Addition of recombinant SIV glycoprotein 120 (rgp120) also resulted in a dose-dependent impairment of T cell maturation in FTOC. The data suggest that in patients infected with HIV, T cell maturation and thus replenishment of peripheral pools may be compromised as a result of intrathymic infection or circulating viral gp120.

Keywords: AIDS, immunodeficiency viruses, T cell development, thymus

The first two authors contributed equally to this work

Transmitting editor: H. R. MacDonald


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