International Immunology, Vol. 11, No. 8, 1357-1362,
August 1999
© 1999 Japanese Society for Immunology
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to I
B kinases
1 Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
2 CREST of Japan Science and Technology Corporation, Japan
3 Department of Oncology, Institute of Medical Science, University of Tokyo, 1-6-4 Shiroganedai, Minatoku, Tokyo 108, Japan
4 Third Department of Internal Medicine, School of Medicine, Kinki University, 2-377 Ohono higashi, Osaka-Sayama, Osaka 589-0014, Japan
Correspondence to: S. Akira
Using the suppression subtractive hybridization technique, we isolated a novel kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS) in the mouse macrophage cell line RAW264.7. The predicted protein contains the kinase domain in its N-terminus, which shares 30% identity to that of IKK-
or IKK-ß. The C-terminal portion contains a leucine zipper and a potential helix-loop-helix domain, as in the case of IKK- and IKK-ß. IKK-i is expressed mainly in immune cells, and is induced in response to proinflammatory cytokines such as tumor necrosis factor-, IL-1 and IL-6, in addition to LPS. Overexpression of wild-type IKK-i phosphorylated serine residues Ser32 and Ser36 of I
B- (preferentially Ser36), and significantly stimulated NF-B activation. These results suggest that IKK-i is an inducible IB kinase which may play a special role in the immune response.
Keywords: IB kinase, inflammation, lipopolysaccharide, macrophage, NF-B
Transmitting editor: S. Nishikawa
5 Present address: Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
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