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International Immunology, Vol. 11, No. 7, 1103-1110, July 1999
© 1999 Japanese Society for Immunology

Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines

Souravi Ghosh and David C. Jackson

Co-Operative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, University of Melbourne, Parkville 3052, Victoria, Australia

Correspondence to: D. C. Jackson

In this study we describe the results of experiments in which a variety of totally synthetic luteinizing hormone releasing hormone (LHRH) vaccines were assembled and examined for their abilities to elicit antibody responses and induce sterility in mice. It is shown that totally synthetic vaccines consisting of a 15 residue-defined T cell epitope and the 10 residue LHRH epitope not only induced high titers of antibody but also induced sterility. This effect did not appear to correlate with antibody titer, antibody isotype or comparative antibody affinity, but may be related to the length of time for which antibodies are present to exert their influence.

Keywords: immunocastration, luteinizing hormone releasing hormone, synthetic vaccine

Transmitting editor: A. Kelso


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