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International Immunology, Vol. 11, No. 6, 951-956, June 1999
© 1999 Japanese Society for Immunology

A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes

Yaron Tikochinski, Dana Elias1, Christiana Steeg1, Hadar Marcus1, Michael Kantorowitz, Tamara Reshef1, Vitaly Ablamunits1, Irun R. Cohen1 and Adam Friedmann

The Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
1 Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel

Correspondence to: I. R. Cohen

T cells involved in autoimmune diseases have been characterized by the genetic elements used to construct their autoimmune TCR. In the present study, we sequenced the {alpha} and ß chains of the TCR expressed by a CD4+ T cell clone, C9, functional in NOD mouse diabetes. Clone C9 can adoptively transfer diabetes or, when attenuated, C9 can be used to vaccinate NOD mice against diabetes. Clone C9 recognizes a peptide epitope (p277) of the 60 kDa heat shock protein (hsp60) molecule. We now report that the C9 TCR ß chain features a CDR3 peptide sequence that is prevalent among NOD mice. This CDR3 element is detectable by 2 weeks of age in the thymus, and later in the spleen and in the autoimmune insulitis. Thus, a TCR CDR3ß sequence appears to be a common idiotope associated with mouse diabetes.

Keywords: CDR3, insulin-dependent diabetes mellitus, TCR

Transmitting editor: L. Steinman


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