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International Immunology, Vol. 11, No. 6, 907-913, June 1999
© 1999 Japanese Society for Immunology

Expansion of neonatal tolerance to self in adult life: II. Tolerance preferentially spreads in an intramolecular manner

Nir Grabie1 and Nathan Karin1,2

1 Department of Immunology, Bruce Rappaport Faculty of Medicine and
2 Rappaport Family Institute for Research in the Medical Sciences, Technion, POB 9697, Haifa 31096, Israel

Correspondence to: N. Karin

Newborn rats exposed to a myelin basic protein determinant acquired long-lasting resistance to experimental autoimmune encephalomyelitis induced by another determinant only if both determinants are co-administered in adult life. We demonstrate here that during the course of disease both the anti-self response and the tolerant state spread in an intramolecular and not an intermolecular manner. Mechanisms involved in tolerance elicitation and expansion are then explored using an in vitro system in which indirect suppression could be measured.

Keywords: experimental autoimmune encephalomyelitis, IL-4, intramolecular deviation, multiple sclerosis, neonatal tolerance, Th1, Th2, tolerizing T cells.

Transmitting editor: L. Steinman


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