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International Immunology, Vol. 11, No. 4, 545-552, April 1999
© 1999 Japanese Society for Immunology

An enlarged subpopulation of T lymphocytes bearing two distinct {gamma}{delta} TCR in an HIV-positive patient

Jean-Luc Taupin, Franck Halary1, Julie Déchanet, Marie-Alix Peyrat1, Jean-Marie Ragnaud2, Marc Bonneville1 and Jean-Franciois Moreau

CNRS UMR 5540, Université de Bordeaux II, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
1 INSERM U463, Institut de Biologie, 9 Quai Moncousu, 44035 Nantes Cedex, France
2 Service de Médecine Interne et Maladies Infectieuses, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux Cedex, France

Correspondence to: J.-L. Taupin

Although T cell clone monospecificity is ensured by several allelic exclusion processes operating at either the genotypic or phenotypic levels, clones expressing two distinct {alpha}ß or {gamma}{delta} TCR have been described in several instances. Thus far, the origin of dual TCR-expressing cells and the homeostatic mechanisms controlling the size of this subset in the periphery remain poorly understood. In the course of a phenotypic analysis of {gamma}{delta} T cells in HIV-infected patients, we detected the presence of a T cell subset stained by both V{delta}2- and V{delta}3-specific mAb, which represented a large fraction (up to 16.5%) of {gamma}{delta} peripheral blood lymphocytes (PBL) in one HIV patient. The presence of two distinct functional {delta} chains on these cells was confirmed by phenotypic and molecular analysis of TCR transcripts expressed by V{delta}2+V{delta}3+ T cell clones derived from this patient. For 18 months, the absolute number of these cells varied similarly to the other PBL subsets, before becoming undetectable in blood samples. Moreover, most of these cells expressed CD8 receptors, which are classically found on activated, but not resting, {gamma}{delta} T cells. Taken together, these data suggest that dual TCR-expressing T cells are subjected to peripheral expansions and contractions presumably following antigen recognition, which would argue against a systematic counter-selection of these cells during peripheral antigen-driven responses.

Keywords: dual TCR, flow cytometry, {gamma}{delta} T lymphocytes

Transmitting editor: A. Fischer


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