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International Immunology, Vol. 11, No. 4, 529-534, April 1999
© 1999 Japanese Society for Immunology

Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats

Shu-Hui Sun, Phyllis B. Silver, Rachel R. Caspi, Ying Du1, Chi-Chao Chan, Ronald L. Wilder1 and Elaine F. Remmers1

Laboratory of Immunology, National Eye Institute, and
1 Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA

Correspondence to: R. R. Caspi, Laboratory of Immunology, National Eye Institute, NIH, Building 10, Room 10N222, 10 Center Drive MSC 1857, Bethesda, MD 20892, USA

The present study attempts to identify specific genetic loci contributing to experimental autoimmune uveoretinitis (EAU) susceptibility in F2 progeny of resistant Fischer (F344/N) and susceptible Lewis (LEW/N) inbred rats. F2 progeny of F344/N x LEW/N inbred rats were immunized with the R16 peptide of interphotoreceptor retinoid-binding protein (IRBP). A genome-wide scan was conducted using 125 simple sequence length polymorphism markers in selected F2 animals that developed severe eye disease or remained unaffected to identify phenotype:genotype co-segregation. The F2 population (n = 1287) demonstrated a wide range of histologically assessed EAU scores (assessed on a scale of 0–4). The disease incidence and severity were not consistent with a simple Mendelian inheritance model. Of the F2 hybrid rats, 60% developed EAU, implying the existence of a potent susceptibility locus with incomplete penetrance associated with the LEW genome or a more complex polygenic model of inheritance. Two genomic regions, on chromosomes 4 and 12, showed strong genetic linkage to the EAU phenotype (P < 0.0016), suggesting the presence of susceptibility loci in these chromosomal regions. In conclusion, we have identified two genomic candidate intervals from D4Arb8 to D4Mit17 on chromosome 4 and from the chromosome end to D12Arb8 on chromosome 12, that appear to influence EAU susceptibility in LEW/F344 rats. Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function.

Keywords: experimental autoimmune uveoretinitis, rat, QTL

Transmitting editor: R. L. Coffman


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