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International Immunology, Vol. 11, No. 3, 373-382, March 1999
© 1999 Japanese Society for Immunology

In vivo elimination of viral superantigen-activated CD4+ T cells: apoptosis occurs at a distance from the activation site

Agnès Le Bon, Anne-Claude Waché and Martine Papiernik

INSERM U345, Institut Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France

Correspondence to: M. Papiernik

Local injection of mouse mammary tumor virus (MMTV) induces a local immune response, with activation of viral superantigen (vSAG)-specific T cell subsets followed by their clonal deletion. We investigated the fate of vSAG-reactive T cells following footpad injection of MMTV(SW) to mice. Activated T cells accumulated in draining lymph nodes. However, we demonstrated that apoptosis did not occur at the activation site, on the contrary of what has been shown after bacterial SAG activation. Although activated T cells were already shown to have the capacity to migrate to the gut, the fate of gut homing cells remains unclear. We demonstrate that the number of vSAG-specific T cells activated in the periphery was increasing in the follicles of gut-associated lymphoid organs, together with the number of apoptotic cell clusters. These results strongly suggested that gut-associated lymphoid tissue was the specific graveyard for apoptotic vSAG-activated CD4 T cells.

Keywords: apoptosis, clonal deletion, viral superantigen

Transmitting editor: J.-F. Bach


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