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International Immunology, Vol. 11, No. 2, 289-296, February 1999
© 1999 Japanese Society for Immunology

Non-coding plasmid DNA induces IFN-{gamma} in vivo and suppresses autoimmune encephalomyelitis

Graciela L. Boccaccio1, Felix Mor1 and Lawrence Steinman1,2

1 The Weizmann Institute of Science, Department of Immunology, Rehovot 76100, Israel
2 Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305–5429, USA

Correspondence to: L. Steinman, Department of Neurology and Neurological Sciences, Beckman B002, Stanford University School of Medicine, Stanford, CA 94305-5429, USA

Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-{gamma}.

Keywords: autoimmunity, cytokines, experimental autoimmune encephalomyelitis, gene therapy, multiple sclerosis, vaccination

Transmitting editor: R. Hardy


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