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International Immunology, Vol. 11, No. 2, 269-277, February 1999
© 1999 Japanese Society for Immunology

HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules

Marta Catálfamo1, Laurence Serradell2, Carme Roura-Mir1, Edgardo Kolkowski1, Mireia Sospedra1, Marta Vives-Pi1, Francesca Vargas-Nieto1, Ricardo Pujol-Borrell1 and Dolores Jaraquemada1,2

1 Unitat d'Immunologia, Hospital Universitari Germans Trias i Pujol,
2 Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

Correspondence to: D. Jaraquemada, Unitat d'Immunologia, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Carretera de Canyet s/n, 08916 Badalona, Spain

Thyroid follicular cells (TFC) in Graves' disease (GD) hyperexpress HLA class I and express ectopic HLA class II molecules, probably as a consequence of cytokines produced by infiltratingT cells. This finding led us to postulate that TFC could act as antigen-presenting cells, and in this way be responsible for the induction and/or maintenance of the in situ autoimmune T cell response. Invariant chain (Ii) and HLA-DM molecules are implicated in the antigen processing and presentation by HLA class II molecules. We have investigated the expression of these molecules by TFC from GD glands. The results demonstrate that class II+ TFC from GD patients also express Ii and HLA-DM, and this expression is increased after IFN-{gamma} stimulation. The level of HLA-DM expression by TFC was low but sufficient to catalyze peptide loading into the HLA class II molecules and form stable HLA class II-peptide complexes expressed at the surface of TFC. These results have implications for the understanding of the possible role of HLA class II+ TFC in thyroid autoimmune disease.

Keywords: class II molecules, peptides, thyroid autoimmunity, thyroid follicular cell

Transmitting editor: M. Feldmannn


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