Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kruse, S.
Right arrow Articles by Deichmann, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kruse, S.
Right arrow Articles by Deichmann, K. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 11, No. 12, 1965-1970, December 1999
© 1999 Japanese Society for Immunology

Characterization of the membrane-bound and a soluble form of human IL-4 receptor {alpha} produced by alternative splicing

Susanne Kruse, Johannes Forster, Joachim Kuehr and Klaus A. Deichmann

University Children's Hospital, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany

Correspondence to: K. A. Deichmann

IL-4 plays a major role in IgE production. Its signal is conferred to effector cells through binding to the {alpha} chain of the membrane-bound human IL-4 receptor (huIL-4R{alpha}). Here we present the genomic structure and organization of huIL-4R{alpha}. The promotor region shows binding sites for several transcription factors involved in inflammatory processes. HuIL-4R{alpha} has been shown to be organized differently to that of mouse IL-4R{alpha}. A soluble form of huIL-4R{alpha} is produced by alternative splicing of the huIL-4R{alpha} gene (shuIL-4R{alpha}/splice). Expression of the corresponding mRNA coding for the extracellular part of the receptor and an additional three amino acids is also shown. A second form of huIL-4R{alpha}, i.e. shuIL-4R{alpha}/prot, is produced by limited proteolysis of the receptor (shedding) and is already known. These results reveal a complex pattern for the regulation of the IL-4 pathway at the receptor level. The patterns of expression of all three receptor proteins as well as their individual meaning in the context of inflammation still have to be elucidated.

Keywords: genomic structure, IL-4 receptor, soluble, splicing

Transmitting editor: A. Radbruch


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
N. Schoof, F. von Bonin, S. Zeynalova, M. Ziepert, W. Jung, M. Loeffler, M. Pfreundschuh, L. Trumper, and D. Kube
Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial
Ann. Onc., September 1, 2009; 20(9): 1548 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. C. Battle, S. Choudhry, H.-J. Tsai, C. Eng, G. Kumar, K. B. Beckman, M. Naqvi, K. Meade, H. G. Watson, M. LeNoir, et al.
Ethnicity-specific Gene-Gene Interaction between IL-13 and IL-4R{alpha} among African Americans with Asthma
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 881 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Epidemiol RevHome page
M. B. Bracken, K. Belanger, W. O. Cookson, E. Triche, D. C. Christiani, and B. P. Leaderer
Genetic and Perinatal Risk Factors for Asthma Onset and Severity: A Review and Theoretical Analysis
Epidemiol. Rev., December 1, 2002; 24(2): 176 - 189.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.