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International Immunology, Vol. 11, No. 12, 1927-1934, December 1999
© 1999 Japanese Society for Immunology

CD4+ T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p 1 independently of IFN-{gamma} production

Sandra Hirschberg, Guy T. Layton1, Stephen J. Harris1, Nigel Savage1, Margaret J. Dallman and Jonathan R. Lamb2

Department of Biology, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
1 British Biotech Pharmaceuticals Ltd, Oxford OX4 5LY, UK
2 Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK

Correspondence to: J. R. Lamb

It has been previously demonstrated that hybrid Ty virus-like particles (VLP) prime effective CD8+ and CD4+ T cell responses. In this study, we investigated the effect of treating mice with Ty VLP carrying the immunodominant epitope of Der p 1 after sensitizing them to the group 1 allergen of the house dust mite Dermatophagoides pteronyssinus (Der p 1), under conditions that induce Th2 immunity. We show that i.p. treatment with the hybrid VLP abrogated allergen-specific IL-5 production and reduced allergen-specific cell proliferation. This suppression of the response was mediated by CD4+ T cells and was not accompanied by an increase in IFN-{gamma} production.

Keywords: CD4, Der p 1, IL-5, IFN-{gamma}


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