International Immunology, Vol 10, 1289-1298, Copyright © 1998 by Oxford University Press
J Borvak, J Richardson, C Medesan, F Antohe, C Radu, M Simionescu, V Ghetie and ES Ward
Our recent data indicate that the MHC class I-related receptor, FcRn, plays
a role in regulating serum IgG levels, in addition to its known role in
transferring IgG from mother to young. In the current study, the
distribution of FcRn in adult mice has been investigated using several
approaches. First, tissue distribution of anti-FcRn F(ab')2, murine IgG1
and recombinant, IgG1-derived Fc-hinge fragments has been analyzed, and
these FcRn binding proteins localize predominantly in skin and muscle with
lesser amounts in liver and adipose tissue. Second, histochemical analyses
of muscle and liver with anti-FcRn F(ab')2 indicate that FcRn is expressed
in the endothelium of small arterioles and capillaries, but not in larger
vessels such as the central vein and portal vasculature. Third,
immunoprecipitation and immunofluorescence studies of cultured murine
endothelial cells show that functional FcRn is expressed in these cells,
and is located within vesicular structures in the cytosol and not on the
membrane. Taken together the data demonstrate that FcRn is expressed in
functionally active form in endothelial cells, indicating that these cells
are a possible site at which serum IgG homeostasis is maintained.
ARTICLES
Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice
Department of Microbiology and Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas 75235-8576, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Sarav, Y. Wang, B. K. Hack, A. Chang, M. Jensen, L. Bao, and R. J. Quigg Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG J. Am. Soc. Nephrol., September 1, 2009; 20(9): 1941 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Montoyo, C. Vaccaro, M. Hafner, R. J. Ober, W. Mueller, and E. S. Ward Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice PNAS, February 24, 2009; 106(8): 2788 - 2793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mi, S. Wanjie, S.-T. Lo, Z. Gan, B. Pickl-Herk, R. J. Ober, and E. S. Ward Targeting the Neonatal Fc Receptor for Antigen Delivery Using Engineered Fc Fragments J. Immunol., December 1, 2008; 181(11): 7550 - 7561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Goebl, C. M. Babbey, A. Datta-Mannan, D. R. Witcher, V. J. Wroblewski, and K. W. Dunn Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells Mol. Biol. Cell, December 1, 2008; 19(12): 5490 - 5505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ye, X. Liu, S. N. Rout, Z. Li, Y. Yan, L. Lu, T. Kamala, N. K. Nanda, W. Song, S. K. Samal, et al. The MHC Class II-Associated Invariant Chain Interacts with the Neonatal Fc{gamma} Receptor and Modulates Its Trafficking to Endosomal/Lysosomal Compartments J. Immunol., August 15, 2008; 181(4): 2572 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, L. Ye, Y. Bai, H. Mojidi, N. E. Simister, and X. Zhu Activation of the JAK/STAT-1 Signaling Pathway by IFN-{gamma} Can Down-Regulate Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG J. Immunol., July 1, 2008; 181(1): 449 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Mezo, K. A. McDonnell, C. A. T. Hehir, S. C. Low, V. J. Palombella, J. M. Stattel, G. D. Kamphaus, C. Fraley, Y. Zhang, J. A. Dumont, et al. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn PNAS, February 19, 2008; 105(7): 2337 - 2342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Jindra, A. Hsueh, L. Hong, D. Gjertson, X.-D. Shen, F. Gao, J. Dang, P. S. Mischel, W. M. Baldwin III, M. C. Fishbein, et al. Anti-MHC Class I Antibody Activation of Proliferation and Survival Signaling in Murine Cardiac Allografts J. Immunol., February 15, 2008; 180(4): 2214 - 2224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Akilesh, T. B. Huber, H. Wu, G. Wang, B. Hartleben, J. B. Kopp, J. H. Miner, D. C. Roopenian, E. R. Unanue, and A. S. Shaw From the Cover: Podocytes use FcRn to clear IgG from the glomerular basement membrane PNAS, January 22, 2008; 105(3): 967 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Dickinson, S. M. Claypool, J. A. D'Angelo, M. L. Aiken, N. Venu, E. H. Yen, J. S. Wagner, J. A. Borawski, A. T. Pierce, R. Hershberg, et al. Ca2+-dependent Calmodulin Binding to FcRn Affects Immunoglobulin G Transport in the Transcytotic Pathway Mol. Biol. Cell, January 1, 2008; 19(1): 414 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Akilesh, G. J. Christianson, D. C. Roopenian, and A. S. Shaw Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism J. Immunol., October 1, 2007; 179(7): 4580 - 4588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liu, A. M. Garcia, H. Santoro, Y. Zhang, K. McDonnell, J. Dumont, and A. Bitonti Amelioration of Experimental Autoimmune Myasthenia Gravis in Rats by Neonatal FcR Blockade J. Immunol., April 15, 2007; 178(8): 5390 - 5398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vaccaro, R. Bawdon, S. Wanjie, R. J. Ober, and E. S. Ward Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies PNAS, December 5, 2006; 103(49): 18709 - 18714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Dall'Acqua, P. A. Kiener, and H. Wu Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) J. Biol. Chem., August 18, 2006; 281(33): 23514 - 23524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Z. Ferl, V. Kenanova, A. M. Wu, and J. J. DiStefano III A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments. Mol. Cancer Ther., June 1, 2006; 5(6): 1550 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kacskovics, Z. Kis, B. Mayer, A. P. West Jr, N. E. Tiangco, M. Tilahun, L. Cervenak, P. J. Bjorkman, R. A. Goldsby, O. Szenci, et al. FcRn mediates elongated serum half-life of human IgG in cattle Int. Immunol., April 1, 2006; 18(4): 525 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Hinton, J. M. Xiong, M. G. Johlfs, M. T. Tang, S. Keller, and N. Tsurushita An Engineered Human IgG1 Antibody with Longer Serum Half-Life J. Immunol., January 1, 2006; 176(1): 346 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Newton, Z. Wu, and N. E. Simister Characterization of basolateral-targeting signals in the neonatal Fc receptor J. Cell Sci., June 1, 2005; 118(11): 2461 - 2469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. B. Wernick, V. Haucke, and N. E. Simister Recognition of the Tryptophan-based Endocytosis Signal in the Neonatal Fc Receptor by the {micro} Subunit of Adaptor Protein-2 J. Biol. Chem., February 25, 2005; 280(8): 7309 - 7316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-J. Kim, T. E. Fandy, V. H. L. Lee, D. K. Ann, Z. Borok, and E. D. Crandall Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L616 - L622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Claypool, B. L. Dickinson, J. S. Wagner, F.-E. Johansen, N. Venu, J. A. Borawski, W. I. Lencer, and R. S. Blumberg Bidirectional Transepithelial IgG Transport by a Strongly Polarized Basolateral Membrane Fc{gamma}-Receptor Mol. Biol. Cell, April 1, 2004; 15(4): 1746 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Ober, C. Martinez, C. Vaccaro, J. Zhou, and E. S. Ward Visualizing the Site and Dynamics of IgG Salvage by the MHC Class I-Related Receptor, FcRn J. Immunol., February 15, 2004; 172(4): 2021 - 2029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kasus-Jacobi, J. Ou, Y. K. Bashmakov, J. M. Shelton, J. A. Richardson, J. L. Goldstein, and M. S. Brown Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated by Sterol Regulatory Element-binding Proteins J. Biol. Chem., August 22, 2003; 278(34): 32380 - 32389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. TUMA and A. L. HUBBARD Transcytosis: Crossing Cellular Barriers Physiol Rev, July 1, 2003; 83(3): 871 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Roopenian, G. J. Christianson, T. J. Sproule, A. C. Brown, S. Akilesh, N. Jung, S. Petkova, L. Avanessian, E. Y. Choi, D. J. Shaffer, et al. The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs J. Immunol., April 1, 2003; 170(7): 3528 - 3533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chaudhury, S. Mehnaz, J. M. Robinson, W. L. Hayton, D. K. Pearl, D. C. Roopenian, and C. L. Anderson The Major Histocompatibility Complex-related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan J. Exp. Med., February 3, 2003; 197(3): 315 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Ward, J. Zhou, V. Ghetie, and R. J. Ober Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans Int. Immunol., February 1, 2003; 15(2): 187 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-J. Kim and A. B. Malik Protein transport across the lung epithelial barrier Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L247 - L259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. D. Acqua, R. M. Woods, E. S. Ward, S. R. Palaszynski, N. K. Patel, Y. A. Brewah, H. Wu, P. A. Kiener, and S. Langermann Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences J. Immunol., November 1, 2002; 169(9): 5171 - 5180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Ober, C. G. Radu, V. Ghetie, and E. S. Ward Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies Int. Immunol., December 1, 2001; 13(12): 1551 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhu, G. Meng, B. L. Dickinson, X. Li, E. Mizoguchi, L. Miao, Y. Wang, C. Robert, B. Wu, P. D. Smith, et al. MHC Class I-Related Neonatal Fc Receptor for IgG Is Functionally Expressed in Monocytes, Intestinal Macrophages, and Dendritic Cells J. Immunol., March 1, 2001; 166(5): 3266 - 3276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McCarthy, M Lam, L Subramanian, R Shakya, Z Wu, E. Newton, and N. Simister Effects of mutations in potential phosphorylation sites on transcytosis of FcRn J. Cell Sci., January 4, 2001; 114(8): 1591 - 1598. [Abstract] [PDF]
|
|
|
|
|
|
J.-P. HAYMANN, J.-P. LEVRAUD, S. BOUET, V. KAPPES, J. HAGEGE, G. NGUYEN, Y. XU, E. RONDEAU, and J.-D. SRAER Characterization and Localization of the Neonatal Fc Receptor in Adult Human Kidney J. Am. Soc. Nephrol., April 1, 2000; 11(4): 632 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Kuan, L. Zuckier, L. Liao, S. M. Factor, and B. Diamond Immunoglobulin Isotype Determines Pathogenicity in Antibody-Mediated Myocarditis in Naive Mice Circ. Res., February 18, 2000; 86(3): 281 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kacskovics, Z. Wu, N. E. Simister, L. V. Frenyo, and L. Hammarstrom Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor J. Immunol., February 15, 2000; 164(4): 1889 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McCarthy, Y Yoong, and N. Simister Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia J. Cell Sci., January 4, 2000; 113(7): 1277 - 1285. [Abstract] [PDF]
|
|
|
|
|
|
Z. Wu and N. E. Simister Tryptophan- and Dileucine-based Endocytosis Signals in the Neonatal Fc Receptor J. Biol. Chem., February 9, 2001; 276(7): 5240 - 5247. [Abstract] [Full Text] [PDF]
|
|