International Immunology, Vol 10, 1185-1196, Copyright © 1998 by Oxford University Press
G Bikah, FM Lynd, AA Aruffo, JA Ledbetter and S Bondada
CD5 is a glycoprotein expressed at a high level on the surface of mature T
lymphocytes. Studies with CD5 mAb and CD5-deficient mice have shown that
the CD5 molecules have a significant role in T cell growth response.
However, the precise role of CD5 in immune cell interactions is still
unclear. The present study provides evidence that CD5 plays a direct role
in providing growth signals during the contact-dependent activation and
proliferation of splenic B cells. An anti-CD5 mAb inhibited Th1- and
Th2-type cell-induced B cell proliferation. CD5-Ig, a chimeric fusion
protein, induced proliferation of resting B cells. Flow cytometric analyses
using CD5-Ig and mAb to CD72 demonstrated that CD5 bound to a ligand
(CD5L), and this binding was not blocked by a variety of anti-CD72 mAb.
Also, CD5-Ig did not bind to CD72+- transfected cells. Immunoprecipitation
of surface labeled B cell molecules with CD5-Ig showed that CD5L was
composed of 77-80 and 38-40 kDa polypeptide chains, distinct from CD72.
CD5L was expressed on activated splenic B cells, but not T cells, whereas
its expression was constitutive on peritoneal B cells and on B lymphoma
cell lines.
ARTICLES
A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5
Department of Microbiology and Immunology and The Sanders Brown Center on Aging, University of Kentucky, Lexington 40536, USA.
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