International Immunology, Vol 10, 1175-1184, Copyright © 1998 by Oxford University Press
UA Betz and W Muller
The functional receptor for the inflammatory cytokine IL-6 is composed of
the ligand binding IL-6 receptor alpha chain (IL-6R alpha) and the signal
transducing chain gp130, which is a shared component of multiple cytokine
receptors. We analyzed the surface expression of gp130 and IL- 6R alpha in
thymocytes and peripheral T cells. While all thymocytes expressed gp130
throughout thymic maturation, they gained expression of IL-6R alpha at the
CD4 or CD8 single-positive stage. Approximately 10- 30% of the CD4-CD8+ and
40-50% of the CD4+CD8- thymocytes expressed IL- 6R alpha. Within the
CD4+CD8- population, the IL-6R alpha- subpopulation was cortisone
sensitive, appeared immature according to the cell surface markers
expressed and failed to proliferate after TCR cross-linking. Peripheral T
cells were predominantly gp130+ and IL-6R alpha+, but down-regulated gp130
and IL-6R alpha expression upon TCR engagement in vitro and in vivo.
Peripheral gp130low/-IL-6R alphalow/- T cells expressed surface markers
characteristic of memory T cells. We show that gp130 and IL-6R alpha are
expressed in a regulated manner in T cells, depending on the developmental
and functional stage.
ARTICLES
Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation
Institute for Genetics, University of Cologne, Germany.
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