International Immunology, Vol 10, 1017-1026, Copyright © 1998 by Oxford University Press
L Liu, BE Rich, J Inobe, W Chen and HL Weiner
A number of observations indicate that exposure to IL-4 is essential for
the priming of Th2-type effector T cells and that exposure to IL-12 is
essential for the priming of Th1-type effector T cells. However, the
initial source of IL-4 in the early immune response has not been clearly
identified. Dendritic cells (DC) are the most potent antigen- presenting
cells (APC) in priming naive T cells. In this report, we show that DC
exposed to IL-10 may play an important role in the priming of
IL-4-secreting cells in the early immune response. DC isolated from splenic
adherent cell cultures treated with rIL-10 (IL-10-DC) primed naive
ovalbumin (OVA)-TCR transgenic T cells to secrete IL-4 upon re- stimulation
with OVA and splenic APC. By contrast, DC isolated from rIL- 12, rIL-4 or
control treated cultures induced almost exclusively Th1- type effector T
cells. IL-4 secretion was detected in the primary cultures of IL-10-DC plus
naive CD4+ T cells and the priming of IL-4- secreting T cells by IL-10-DC
was dependent on endogenous IL-4 production in the priming culture since
anti-IL-4 neutralizing antibody completely abrogated the priming of
IL-4-secreting cells. Anti-B7-2 but not anti-B7-1 inhibited the ability of
IL-10-DC to prime T cells to secrete IL-4. Furthermore, the ability of
IL-10 DC to prime for IL-4- secreting T cells was closely related to the
down-regulation of CD40 ligand-mediated IL-12 p70 production by DC in the
primary cultures and was markedly reduced by adding exogenous IL-12 to the
priming cultures. Thus, our findings indicate that early immunologic events
that drive Th2 differentiation involve the effects of IL-10 on DC.
ARTICLES
Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Okunishi, M. Dohi, K. Fujio, K. Nakagome, Y. Tabata, T. Okasora, M. Seki, M. Shibuya, M. Imamura, H. Harada, et al. Hepatocyte Growth Factor Significantly Suppresses Collagen-Induced Arthritis in Mice J. Immunol., October 15, 2007; 179(8): 5504 - 5513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wang, S. Hong, J. Yang, J. Qian, X. Zhang, E. Shpall, L. W. Kwak, and Q. Yi Optimizing immunotherapy in multiple myeloma: restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells Blood, December 15, 2006; 108(13): 4071 - 4077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ejrnaes, C. M. Filippi, M. M. Martinic, E. M. Ling, L. M. Togher, S. Crotty, and M. G. von Herrath Resolution of a chronic viral infection after interleukin-10 receptor blockade J. Exp. Med., October 30, 2006; 203(11): 2461 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wang, J. Yang, J. Qian, M. Wezeman, L. W. Kwak, and Q. Yi Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma Blood, March 15, 2006; 107(6): 2432 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Safadi, C. E. Alvarez, M. Ohta, J. Brimnes, T. Kraus, W. Mehal, J. Bromberg, L. Mayer, and S. L. Friedman Enhanced Oral Tolerance in Transgenic Mice with Hepatocyte Secretion of IL-10 J. Immunol., September 15, 2005; 175(6): 3577 - 3583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-K. Ip and Y.-L. Lau Distinct Maturation of, but Not Migration between, Human Monocyte-Derived Dendritic Cells upon Ingestion of Apoptotic Cells of Early or Late Phases J. Immunol., July 1, 2004; 173(1): 189 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hill, T. E. Ichim, K. P. Kusznieruk, M. Li, X. Huang, X. Yan, R. Zhong, E. Cairns, D. A. Bell, and W.-P. Min Immune Modulation by Silencing IL-12 Production in Dendritic Cells Using Small Interfering RNA J. Immunol., July 15, 2003; 171(2): 691 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Vieira, H. C. Heystek, J. Wormmeester, E. A. Wierenga, and M. L. Kapsenberg Glatiramer Acetate (Copolymer-1, Copaxone) Promotes Th2 Cell Development and Increased IL-10 Production Through Modulation of Dendritic Cells J. Immunol., May 1, 2003; 170(9): 4483 - 4488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Kammerer, A. O. Eggert, M. Kapp, A. D. McLellan, T. B. H. Geijtenbeek, J. Dietl, Y. van Kooyk, and E. Kampgen Unique Appearance of Proliferating Antigen-Presenting Cells Expressing DC-SIGN (CD209) in the Decidua of Early Human Pregnancy Am. J. Pathol., March 1, 2003; 162(3): 887 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Rigby, T. Rouse, and E. H. Field Total lymphoid irradiation nonmyeloablative preconditioning enriches for IL-4-producing CD4+-TNK cells and skews differentiation of immunocompetent donor CD4+ cells Blood, March 1, 2003; 101(5): 2024 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Katakai, K. J. Mori, T. Masuda, and A. Shimizu Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or {alpha}4{beta}7-integrin at the lesions of autoimmune gastritis Int. Immunol., February 1, 2002; 14(2): 167 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Slavin, R. Maron, and H. L. Weiner Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes Int. Immunol., June 1, 2001; 13(6): 825 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, I. Goldschneider, J. O’Rourke, and R. E. Cone Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation J. Leukoc. Biol., May 1, 2001; 69(5): 741 - 746. [Abstract] [Full Text]
|
|
|
|
|
|
T. Ito, R. Amakawa, M. Inaba, S. Ikehara, K. Inaba, and S. Fukuhara Differential Regulation of Human Blood Dendritic Cell Subsets by IFNs J. Immunol., March 1, 2001; 166(5): 2961 - 2969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Vieira, E. C. de Jong, E. A. Wierenga, M. L. Kapsenberg, and P. Kalinski Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction J. Immunol., May 1, 2000; 164(9): 4507 - 4512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Wendling, L. Paul, R. van der Zee, B. Prakken, M. Singh, and W. van Eden A Conserved Mycobacterial Heat Shock Protein (hsp) 70 Sequence Prevents Adjuvant Arthritis upon Nasal Administration and Induces IL-10-Producing T Cells That Cross-React with the Mammalian Self-hsp70 Homologue J. Immunol., March 1, 2000; 164(5): 2711 - 2717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Demeure, H. Tanaka, V. Mateo, M. Rubio, G. Delespesse, and M. Sarfati CD47 Engagement Inhibits Cytokine Production and Maturation of Human Dendritic Cells J. Immunol., February 15, 2000; 164(4): 2193 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Khanna, A. E. Morelli, C. Zhong, T. Takayama, L. Lu, and A. W. Thomson Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo J. Immunol., February 1, 2000; 164(3): 1346 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Hashimoto, T. Suzuki, H.-Y. Dong, S. Nagai, N. Yamazaki, and K. Matsushima Serial Analysis of Gene Expression in Human Monocyte-Derived Dendritic Cells Blood, August 1, 1999; 94(3): 845 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Urban, N. Willcox, and D. J. Roberts A role for CD36 in the regulation of dendritic cell function PNAS, July 17, 2001; 98(15): 8750 - 8755. [Abstract] [Full Text] [PDF]
|
|