International Immunology, Vol 10, 237-240, Copyright © 1998 by Oxford University Press
V Kronin, D Vremec and K Shortman
The IL-2 receptor (IL-2R) alpha chain (CD25), but not the IL-2R beta chain,
is induced on dendritic cells (DC) by brief periods of culture. To test if
this IL-2R alpha is important for DC function, DC were isolated from the
spleens of mutant mice with the IL-2R alpha gene disrupted and compared
with normal DC for ability to stimulate proliferation of allogeneic CD4 and
CD8 T cells in culture. The IL-2R alpha null DC and the normal DC produced
nearly identical proliferative responses from CD4 and from CD8 T cells.
When the CD8 alpha+ and CD8 alpha- subsets of the IL-2R alpha null DC were
separated, they also produced proliferative responses similar to that of
their normal DC counterparts. Overall there was no evidence that the
inducible IL-2R alpha on DC was required for DC development, for
stimulation of T cells or for regulation of T cell responses.
ARTICLES
Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
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