International Immunology, Vol 10, 231-236, Copyright © 1998 by Oxford University Press
J Wang, ND Griggs, KS Tung and JR Klein
Neonatal thymectomy (NTX) of BALB/c mice between days 1 and 3 post- birth
leads to a high incidence of autoimmune gastritis involving T cells and
autoantibodies. Although progress has been made in understanding various
immunological events associated with that disease process, much remains to
be learned about the regulatory factors which control autoimmune gastritis.
In this study we have examined the potential for neuroendocrine hormones of
the hypothalamus-pituitary- thyroid (HPT) axis to alter the outcome of
experimental autoimmune gastritis in NTX mice. As reported here, thyroxine
administered to young adult NTX mice during an active phase of disease
development dramatically reduced the incidence of gastritis and the overall
severity of disease, and lowered the levels of anti-parietal cell
antibodies. In contrast, treatment of young NTX mice with thyroxine or
other HPT hormones prior to the onset of disease had no beneficial effect
on gastritis, but instead resulted in significantly higher anti- parietal
cell antibody levels compared to non-hormone-treated NTX mice or to NTX
mice treated as adults. Reverse transcriptase spectratype analyses of 22
Vbeta gene junctional sites revealed pronounced oligoclonality and limited
junctional diversity in stomach lymphocytes from untreated NTX mice
compared to normal mice or thyroxine-treated NTX mice. These findings
identify a set of dynamic immune-endocrine interactions, linked to critical
development-dependent events, that are involved in the expression and
regulation of peripheral autoimmunity.
ARTICLES
Dynamic regulation of gastric autoimmunity by thyroid hormone
Department of Biological Science and the Mervin Bovaird Center for Studies in Molecular Biology and Biotechnology, University of Tulsa, OK 74104, USA.
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